SSTR2 - somatostatin receptor 2 Gene

Also Known as SST2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6752

About SSTR2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:73,165,010-73,176,633 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues and 17 paralogues. Biased expression in brain (RPKM 12.7), adrenal (RPKM 3.5) and 10 other tissues.

Summary

Somatostatin acts at many sites to inhibit the release of many Hormones and Other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]

SSTR2 Products (1)

mRNA	Protein	Name
NM_001050.3	NP_001041.1	somatostatin receptor type 2

SSTR2 Protein Structure

7tm_1

0
100
200
300
369 a.a.

Protein Preferred Names	Protein Names
somatostatin receptor type 2	SRIF-1 SS2R

SSTR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SSTR2	P30874	SSTR3	Homo sapiens	P32745	Anti Tag CoIP	22651821
Intra	SSTR2	P30874	SSTR3	Homo sapiens	P32745	FRET	22651821
Intra	SSTR2	P30874	PIK3R1	Homo sapiens	P27986	Pull Down	16917505

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SSTR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700430	SSTR2 Protein-VLP, Human (HEK293, His)	P30874 (M1-I369)	Purity analysis by SDS-PAGE is not available for VLP proteins.

SSTR2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81452	Somatostatin Receptor 2 Antibody (YA1197)	IHC-P	Human
HY-P81452A	Somatostatin Receptor 2 Antibody (YA1197)(PBS only)	IHC-P	Human
HY-P84249	Somatostatin Receptor 2 Antibody (YA3946)	FC, ELISA	Human
HY-P84249A	Somatostatin Receptor 2 Antibody (YA3946)(PBS only)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Acth-Secreting Pituitary Adenoma	Acth-Producing Pituitary Adenoma Corticotroph Adenoma Corticotropinoma Pituitary-Dependent Cushing'S Disease Adrenal Gland Hyperfunction Cushing Syndrome
Gastrointestinal Neuroendocrine Tumor	Gastrointestinal Neuroendocrine Tumour Malignant Gastrointestinal Neuroendocrine Tumor Malignant Gastrointestinal Neuroendocrine Tumour Digestive System Neuroendocrine Neoplasm Digestive System Neuroendocrine Tumor
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Pulmonary Neuroendocrine Tumor	Neuroendocrine Neoplasm Of Lung
Skull Base Cancer	Tumors Of Skull Base Skull Base Neoplasms
Paraganglioma	Chemodectoma Glomus Body Tumor Paragangliomas Carotid Body Paraganglioma Extra-Adrenal Paraganglioma
Hormone Producing Pituitary Cancer	Growth Hormone Producing Pituitary Tumor Pituitary Tumors, Hormone Producing Somatotropinoma Growth Hormone-Producing Pituitary Gland Neoplasm
Prolactinoma	Prolactin-Producing Pituitary Gland Adenoma Prolactin-Secreting Pituitary Adenoma Forbes-Albright Syndrome Lactotroph Adenoma Prl-Secreting Pituitary Adenoma Prloma Pituitary Lactotrophic Adenoma Familial Prolactinoma Pituitary Adenoma, Prolactin-Secreting Prolactinoma Of Pituitary Gland PSPA
Pituitary Carcinoma	Pituitary Cancer Carcinoma Of The Pituitary Gland Malignant Neoplasm Of Pituitary Gland
Intracranial Meningioma	Meningioma
Endocrine Organ Benign Neoplasm
Solitary Fibrous Tumor/Hemangiopericytoma	Sft/Hpc
Hyperinsulinemic Hypoglycemia	Nesidioblastosis Islet Cell Hyperplasia Persistent Hyperinsulinemia Hypoglycemia Of Infancy Hyperinsulinemic Hypoglycaemia
Microcystic Meningioma
Optic Nerve Neoplasm	Optic Nerve Neoplasms Neoplasm Of Optic Nerve Tumor Of Second Cranial Nerve Tumour Of Optic Nerve
Functioning Pituitary Adenoma	Secretory Adenoma Of The Pituitary Gland Endocrine Active Pituitary Adenoma Secreting Pituitary Adenoma Pituitary Adenoma, Functioning
Pituitary Gland Disease	Pituitary Diseases Pituitary Dysfunction Pituitary Disease Pituitary Deficiency Pituitary Disorders
Thyroid Gland Medullary Carcinoma	Medullary Thyroid Carcinoma Medullary Carcinoma Of The Thyroid Gland Ultimobranchial Thyroid Tumor Ultimobranchial Thyroid Tumour Thyroid Cancer, Medullary
Thyroid Gland Cancer	Thyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre
Hyperpituitarism
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Growth Hormone Secreting Pituitary Adenoma	Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma Growth Hormone Producing Adenoma Of The Pituitary Growth Hormone Secreting Adenoma Of Pituitary
Esophageal Neuroendocrine Tumor	Esophageal Neuroendocrine Tumour Neuroendocrine Tumor Of Esophagus Neuroendocrine Tumour Of Oesophagus
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Skull Base Meningioma	Meningioma Of The Skull Base
Gastrinoma	Gastrin Cell Tumour Gastrin Secreting Tumor Malignant Gastrinoma Gastrinoma, Malignant
Somatostatinoma	Somatostatin Cell Neoplasm Somatostatin Cell Tumour Ampullary Somatostatinoma Carcinoid Somatostatinoma Malignant Islet Cell Tumor Somatomedin-Secreting Carcinoid Somatostatin-Secreting Pancreatic Neoplasm Pancreatic Somatostatinoma Pancreatic Endocrine Carcinoma
Pituitary Adenoma	Pituitary Neoplasms Adenoma Of The Pituitary Gland Pituitary Adenomas Adenoma, Pituitary Pituitary Gland Adenoma
Insulinoma	Islet Cell Adenoma Insulin-Producing Tumor Of Islet Cells Adenoma Islet Cell Islet Cell Tumor Experimental Organism Islet Cell Adenoma Neoplasm
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Neuroendocrine Tumor	Neuroendocrine Neoplasm Neuroendocrine Tumors Carcinoma, Neuroendocrine
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Meningothelial Meningioma	Meningotheliomatous Meningioma
Optic Nerve Sheath Meningioma	Meningioma Of Optic Nerve Sheath
Endocrine Pancreas Disease	Disorder Of Endocrine Pancreas
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Psammomatous Meningioma
Pancreatic Endocrine Carcinoma	Carcinoma Of Endocrine Pancreas Islet Cell Carcinoma Malignant Neoplasm Of Islets Of Langerhans Pancreatic Neuroendocrine Carcinoma Carcinoma Islet Cell Carcinoma, Islet Cell
Pancreatic Cystadenoma	Cystadenoma Of Pancreas
Thyroid Carcinoma, Familial Medullary	Medullary Thyroid Carcinoma Familial Medullary Thyroid Carcinoma MTC Fmtc Mtc1 Thyroid Cancer, Medullary Medullary Thyroid Cancer Thyroid Carcinoma, Medullary Familial Mtc Thyroid Carcinoma Medullary Carcinoma, Thyroid, Medullary, Familial Medullary Carcinoma Of Thyroid Medullary Carcinoma With Amyloid Stroma, Unspecified Site Medullary Carcinoma With Amyloid Stroma Of Thyroid
Cranial Nerve Malignant Neoplasm	Cranial Nerve Neoplasms Malignant Neoplasm Of Cranial Nerve Malignant Tumor Of Cranial Nerve Malignant Tumor Of The Cranial Nerve
Islet Cell Tumor	Pancreatic Neuroendocrine Tumor Neuroendocrine Tumor Of Pancreas Pnet Pancreatic Net Well-Differentiated Nen Of Pancreas Well-Differentiated Neuroendocrine Neoplasm Of Pancreas Well-Differentiated Pancreatic Nen Well-Differentiated Pancreatic Neuroendocrine Neoplasm Endocrine Pancreas Cancer Islet Cell Neoplasm Islet Cell Tumour Malignant Pancreatic Endocrine Tumor Malignant Pancreatic Endocrine Tumour Malignant Tumor Of Endocrine Pancreas Malignant Tumour Of Endocrine Pancreas Pancreatic Endocrine Neoplasm Pancreatic Endocrine Tumor Pancreatic Neuroendocrine Neoplasm Adenoma, Islet Cell Well Differentiated Pancreatic Endocrine Tumor Malignant Neoplasm Of Endocrine Pancreas Pancreatic Endocrine Carcinoma
Acromegaly	Gigantism Growth Hormone Excess Pituitary Giant Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma
Carcinoid Tumors, Intestinal	Gastrointestinal Carcinoid Tumor Argentaffinoma Carcinoid Intestinal Carcinoid Tumor ICT Tumor, Carcinoid, Intestinal Malignant Carcinoid Syndrome Carcinoid Tumor Of Intestine Carcinoid Tumor Carcinoid Tumor No Icd-O Subtype
Brain Meningioma	Intracranial Meningioma
Angiomatous Meningioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0036	Octreotide	Agonist	99.96%	Unkown
HY-P0036B	Octreotide pamoate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P5362	NODAGA-LM3	Antagonist	99.65%	Phase 2
HY-P0024	Veldoreotide	Activator	/	Phase 2
HY-106103	Seglitide	Modulator	99.30%	Phase 2
HY-P3294	Onzigolide	Agonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1932	Cortistatin-14		99.98%	Unkown
HY-P1202	CYN 154806	Antagonist	99.90%	Unkown
HY-P10137	Satoreotide	Antagonist	98.80%	Unkown
HY-P3124A	BIM-23190 hydrochloride	Agonist	99.33%	Unkown
HY-P1202A	CYN 154806 TFA	Antagonist	98.30%	Unkown
HY-P0024A	Veldoreotide TFA	Agonist	98.97%	Unkown
HY-P4452	PRL 2915	Antagonist	99.92%	Unkown
HY-P2090A	Angiopeptin TFA	Agonist	99.01%	Unkown
HY-P3618	Cortistatin-29 (reduced)		98.12%	Unkown
HY-P5362A	NODAGA-LM3 TFA	Antagonist	/	Unkown
HY-P4469	PRL 3195	Antagonist	/	Unkown
HY-P10239	Tyr3-Octreotate	Ligand	99.76%	Unkown
HY-P2545	[Tyr1]-Somatostatin-14		/	Unkown
HY-P2150	Cortistatin-29 (rat)		/	Unkown
HY-P0042	BIM-23197	Agonist	/	Unkown
HY-P11485	JR11-PEG3-HBED-CC-PSMA-03	Antagonist	/	Unkown
HY-110161	sst2 Receptor agonist-1	Agonist	/	Unkown
HY-P3124	BIM-23190	Agonist	/	Unkown
HY-P2090	Angiopeptin	Agonist	/	Unkown
HY-P11488	JR11-PEG3-DOTA-PSMA-03	Ligand	/	Unkown
HY-P2434	AP102		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SSTR2	VGNC	VGNC:46844
Bos taurus	SSTR2	VGNC	VGNC:35326
Rattus norvegicus	SSTR2	RGD	RGD:3763
Macaca mulatta	SSTR2	VGNC	VGNC:77893
Felis catus	SSTR2	VGNC	VGNC:65711
Mus musculus	SSTR2	MGD	MGI:98328
Others	SSTR2	NCBI